An International Conference on Science and Culture will be held in Losinj, Croatia, from 17 to 19 September in honour of Paolo Budinich, a 'founding father' of ICTP and SISSA (International School for Advanced Studies) in Trieste and a leading advocate of scientific cooperation with central and eastern European countries. The conference is being organized on the occasion of Budinich's 85th birthday. On 22 September, ICTP will dedicate a Symposium on Future Challenges in Science to Daniele Amati, who succeeded Budinich as Director of SISSA in 1986 and then served in that capacity for the next 15 years (he will be stepping down as director this fall). The event, to be held in the ICTP Main Lecture Hall, will also serve as an occasion to celebrate Amati's 70th birthday.